Article
Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.
Circulation research - 5 Jun 2009
Remme Carol Ann, Scicluna Brendon P, Verkerk Arie O, Amin Ahmad S, van Brunschot Sandra, Beekman Leander, Deneer Vera H M, Chevalier Catherine, Oyama Fumitaka, Miyazaki Haruko, Nukina Nobuyuki, Wilders Ronald, Escande Denis, Houlgatte Rémi, Wilde Arthur A M, Tan Hanno L, Veldkamp Marieke W, de Bakker Jacques M T, Bezzina Connie R
Abstract excerpt
Conduction slowing of the electric impulse that drives the heartbeat may evoke lethal cardiac arrhythmias. Mutations in SCN5A, which encodes the pore-forming cardiac sodium channel alpha subunit, are associated with familial arrhythmia syndromes based on conduction slowing. However, disease severity among mutation carriers is highly variable. We hypothesized that genetic modifiers underlie the variability in...
Topics
- Animals
- Arrhythmias, Cardiac
- Channelopathies
- DNA Transposable Elements
- Heart Conduction System
- Heart Ventricles
- Mice
- Mice, Inbred Strains