Article

Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads

2026-05-06

Abstract excerpt

Targeting membrane receptors underlies the success of antibody-drug conjugates (ADCs), yet single-receptor formats can be limited by heterogeneous expression, compensatory signaling, and variable internalization. Here we developed Multivalent Interchangeable Nanobody Degradation System (MINDS), a modular nanobody-Fc chassis that co-engages multiple membrane receptors, promotes their lysosomal co-depletion, and ena...

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Literature Corpus work: 0b0c39a5-1e83-5857-bf21-dfe607727451
DOI: 10.64898/2026.05.02.722401

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