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RFX3 is essential for the generation of functional human pancreatic islets from stem cells

23 Apr 2025

Abstract excerpt

AIMS/HYPOTHESIS: The role of regulatory factor X 3 (RFX3) in human pancreatic islet development has not been explored. This study aims to investigate the function of RFX3 in human pancreatic islet development using human islet organoids derived from induced pluripotent stem cells (iPSCs), hypothesising that RFX3 regulates human islet cell differentiation. METHODS: We generated RFX3 knockout (RFX3 KO) iPSC lines...

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PMID: 40263183
DOI: 10.1007/s00125-025-06424-4

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