Article

RFX3 is essential for the development and maturation of human pancreatic islets derived from pluripotent stem cells

2024-09-19

Abstract excerpt

RFX3 in human pancreatic islet development has not been explored. This study aims to investigate the function of RFX3 in human pancreatic islet development using human islet organoids derived from iPSCs, hypothesizing that RFX3 regulates human islet cell differentiation. We generated RFX3 knockout ( RFX3 KO) iPSC lines using CRISPR/Cas9 and differentiated them into pancreatic islet organoids. Various techniques...

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Literature Corpus work: 9cd4c968-0504-531b-b634-db2ff7874dfd
DOI: 10.1101/2024.09.18.613711

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