Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dual role of RFX6 in directing β cell development and insulin production.

Journal of molecular endocrinology - 1 Feb 2021

Lu Jing, Cheng Cheng, Cheng Zhen-Chao, Wu Qian, Shen Han, Yuan Ming-Xia, Zhang Bo, Yang Jin-Kui

Abstract excerpt

RFX6 transcription factor is believed to play a central role in directing cell development of insulin-producing pancreatic islet. RFX6 homozygous mutations cause syndromic neonatal diabetes with hypoplastic pancreas. However, RFX6 heterozygous mutations cause maturity-onset diabetes of the young (MODY) with normal pancreas development. Here, we show that RFX6 may control islet cell development and insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Experimental
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Ontology

Share to Insulin-Secreting Cells

Share to Protein Biosynthesis

Share to Regulatory Factor X Transcription Factors

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 33350979
DOI: 10.1530/JME-20-0119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dual role of RFX6 in directing β cell development and insulin production.PMID 33350979Read ↗

Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitorsSemantic proximity Read ↗

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function.Semantic proximity Read ↗

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-CellsSemantic proximity Read ↗

Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.Semantic proximity Read ↗

Rfx6 Maintains the Functional Identity of Adult Pancreatic β CellsSemantic proximity Read ↗

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β CellsSemantic proximity Read ↗

The Transcription Factor Rfx3 Regulates β-Cell Differentiation, Function, and Glucokinase ExpressionSemantic proximity Read ↗

Human iPSC-based modeling reveals coding and non-coding transcriptomic alterations associated with RFX3 deficiency in pancreatic isletsSemantic proximity Read ↗

RFX3 is essential for the development and maturation of human pancreatic islets derived from pluripotent stem cellsSemantic proximity Read ↗

Mitchell-Riley syndrome iPSCs exhibit reduced pancreatic endoderm differentiation due to a mutation in RFX6.Semantic proximity Read ↗

Rfx6 directs islet formation and insulin production in mice and humansSemantic proximity Read ↗

RFX3 is essential for the generation of functional human pancreatic islets from stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.