Article

Impact of proteogenomic evidence on clinical success

2026-02-25

Abstract excerpt

We assessed the impact of plasma protein quantitative trait loci (pQTL) on therapeutic hypotheses backed by human genetic evidence. We show that pQTL-supported target-indication pairs were 4.7 times more likely to advance from Phase I to launch, compared to a 2.6-fold increase observed only with human genetic evidence. Moreover, pQTL-based enrichment was prominent in druggable protein families which had limited en...

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Literature Corpus work: 8605e990-2045-529a-8e7e-bb84d0486bfc
DOI: 10.64898/2026.02.23.26346731

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