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Article

Variant of uncertain significance Arg866Cys enhances disorderedness of h-BRCA1 (759-1064) region.

The international journal of biochemistry & cell biology - 1 Mar 2024

Mishra Neha, Dubey Suchita, Kumari Anchala, Siddiqui M Quadir, Kuligina Ekaterina, Varma Ashok K

Abstract excerpt

High structural flexibility has been reported in the central region of BRCA1, which hinders the structural and functional evaluations of mutations identified in the domain. Additionally, the need to categorize variants of unknown significance (VUS) has increased due to the growth in the number of variants reported in clinical settings. Therefore, unraveling the disease-causing mechanism of VUS identified in...

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PMID: 38242199
DOI: 10.1016/j.biocel.2024.106527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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