An in silico approach to investigate the source of the controversial interpretations about the phenotypic results of the human AhR-gene G1661A polymorphism.

doi:10.1016/j.jtbi.2016.01.001

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Article

An in silico approach to investigate the source of the controversial interpretations about the phenotypic results of the human AhR-gene G1661A polymorphism.

Journal of theoretical biology - 21 Mar 2016

Aftabi Younes, Colagar Abasalt Hosseinzadeh, Mehrnejad Faramarz

Abstract excerpt

Aryl hydrocarbon receptor (AhR) acts as an enhancer binding ligand-activated intracellular receptor. Chromatin remodeling components and general transcription factors such as TATA-binding protein (TBP) are evoked on AhR-target genes by interaction with its flexible transactivation domain (TAD). AhR-G1661A single nucleotide polymorphism (SNP: rs2066853) causes an arginine to lysine substitution in the acidic...

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PMID: 26776670
DOI: 10.1016/j.jtbi.2016.01.001

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