Article

T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity

2026-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Interferon regulatory factor 1 (IRF1) has long been recognized as a tumor suppressor; however, recent studies have revealed context-specific and sometimes opposing roles in cancer progression. Here, we describe a T cell–specific mechanism underlying the antitumor activity of IRF1. Unlike germline Irf1 -deficient mice, T cell–specific loss of IRF1 does not lead to a deficiency in cytotoxic CD8⁺...

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Literature Corpus work: bd2f4858-2462-5959-9e1e-e3f83c19b3d7
DOI: 10.64898/2026.05.14.725206

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