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Article

PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

2021-07-28

Abstract excerpt

Despite the success of immune checkpoint inhibitor (ICI) therapy in different cancers, resistance and relapses are frequent. Thus, combination therapies are expected to enhance response rates and overcome resistance to ICIs. Herein, we report that combining protein arginine methyltransferase 7 (PRMT7) inhibition with ICIs triggers a strong anti-tumor T cell immunity and restrains tumor growth in vivo by increasin...

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Literature Corpus work
a9e0bbe5-68f9-5bba-b913-e10ce1c97fc8
DOI
10.1101/2021.07.28.454202
Open publication

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PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockadeDOI 10.1101/2021.07.28.454202
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