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Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden

2024-02-06

Abstract excerpt

Aquaporin-4 (AQP4) is an integral component of the glymphatic system, today considered a crucial pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clinical outcome in Alzheimer’s disease as well as sleep measures. We examined whether a risk score calculated from several AQP4 single-nucleotide polymorphisms (SNPs) is related to...

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Literature Corpus work
bd2e1205-448c-5e2e-9ce6-219f1f5febf8
DOI
10.1101/2024.02.05.24302223
Open publication

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Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burdenDOI 10.1101/2024.02.05.24302223
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