Article
Amyloid Precursor Protein Processing Links Female Urgency Urinary Incontinence with Alzheimer's Disease: Implications for Treatment.
International journal of molecular sciences - 9 Jul 2026
Post Wilke M, Widomska Joanna, Oosterwijk Egbert, De Witte Ward, Tiemessen Dorien M, Klemann Cornelius J H M, Ruisch Il Hyun, Coenen Marieke J H, Janssen Dick A W, Martens Frank, Carnes Megan U, Marks Jesse A, Page Grier P, Richter Holly E, Cartwright Rufus, Minassian Vatche A, Thomas Laurent F, Skogholt Anne H, Stafne Signe N, Hveem Kristian, Kluivers Kirsten B, Poelmans Geert
Abstract excerpt
Urgency urinary incontinence (UUI) and Alzheimer's disease (AD) are highly comorbid conditions in women, but the underlying molecular mechanisms are largely unknown. Therefore, we used network enrichment analyses and an elaborate literature search to integrate the most significant genes from four genome-wide association studies (GWASs) and other genetic, expression and functional evidence into a molecular...
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