Article

Leveraging Homologous Recombination Deficiency via the Repositioned Prodrug CB1954

2026-07-09

Abstract excerpt

<h4> A bstract </h4> Homologous recombination deficiency (HRD) is an actionable vulnerability found in a substantial fraction of human cancers, yet current HRD-directed therapies are limited by toxicity, incomplete responses, and acquired resistance. Many DNA-damaging agents were developed before DNA repair biomarkers were available, suggesting that abandoned agents may harbor previously unrecognized genotype-s...

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Literature Corpus work: bd253591-c572-5436-948d-6bf6c3a841f5
DOI: 10.64898/2026.07.08.737246

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