Article

Inhibition of the ubiquitin-proteasome system by a bioactivatable compound

2021-03-16

Abstract excerpt

<h4>Summary</h4> Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of the bioactivatable compound CBK77, which causes an irreversible collapse of the UPS, accompanied by a general accumulation of ubiquitylated proteins and ca...

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Literature Corpus work: 71127b11-2520-5d64-8217-02ee7091e88a
DOI: 10.1101/2021.03.16.435589

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