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Article

Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity.

DNA repair - 1 Apr 2015

Sousa Fabricio G, Matuo Renata, Tang Sai-Wen, Rajapakse Vinodh N, Luna Augustin, Sander Chris, Varma Sudhir, Simon Paul H G, Doroshow James H, Reinhold William C, Pommier Yves

Abstract excerpt

Loss of function of DNA repair (DNAR) genes is associated with genomic instability and cancer predisposition; it also makes cancer cells reliant on a reduced set of DNAR pathways to resist DNA-targeted therapy, which remains the core of the anticancer armamentarium. Because the landscape of DNAR defects across numerous types of cancers and its relation with drug activity have not been systematically examined, we...

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Identifiers

PMID: 25758781
DOI: 10.1016/j.dnarep.2015.01.011
PMCID: PMC4385398

Genes

SLX4
SLFN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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