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Article

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

15 May 2019

Abstract excerpt

gene expression. This down-regulation was seen in mouse tumor xenografts but not in mouse bone marrow, providing a therapeutic window for combining cediranib and olaparib in cancer therapy. Our work reveals a treatment strategy by which DNA repair can be manipulated in human tumors to induce synthetic lethality, broadening the potential therapeutic scope of cediranib based on its activity as a DNA repair inhibitor.

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PMID: 31092693
DOI: 10.1126/scitranslmed.aav4508

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