Article
Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System.
mBio - 21 Dec 2021
Yu Chen-Hsin, Sephton-Clark Poppy, Tenor Jennifer L, Toffaletti Dena L, Giamberardino Charles, Haverkamp Miriam, Cuomo Christina A, Perfect John R
Abstract excerpt
Cryptococcus neoformans is a major human central nervous system (CNS) fungal pathogen causing considerable morbidity and mortality. In this study, we provide the widest view to date of the yeast transcriptome directly from the human subarachnoid space and within cerebrospinal fluid (CSF). We capt...
Topics
- Animals
- Central Nervous System
- Cryptococcosis
- Cryptococcus neoformans
- Disease Models, Animal
- Female
- Fungal Proteins
- Genotype
- Humans
- Male
- Meningoencephalitis
- Mice
- RNA-Seq
- Rabbits
- Transcriptome
- Virulence