Article
Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii.
mBio - 1 Sept 2015
Farrer Rhys A, Desjardins Christopher A, Sakthikumar Sharadha, Gujja Sharvari, Saif Sakina, Zeng Qiandong, Chen Yuan, Voelz Kerstin, Heitman Joseph, May Robin C, Fisher Matthew C, Cuomo Christina A
Abstract excerpt
UNLABELLED: Cryptococcus gattii is a fungal pathogen of humans, causing pulmonary infections in otherwise healthy hosts. To characterize genomic variation among the four major lineages of C. gattii (VGI, -II, -III, and -IV), we generated, annotated, and compared 16 de novo genome assemblies, including the first for the rarely isolated lineages VGIII and VGIV. By identifying syntenic regions across assemblies, we...
Topics
- Animals
- Cluster Analysis
- Cryptococcosis
- Cryptococcus gattii
- DNA, Fungal
- Environmental Microbiology
- Evolution, Molecular
- Genetic Variation
- Genome, Fungal
- Genotype