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Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

24 Apr 2020

Abstract excerpt

Mitochondria plays privotal role in diverse pathways that regulate cellular function and survival, and have emerged as a prime focus in aging and age-associated motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Accumulating evidence suggests that many amyloidogenic proteins, including MND-associated RNA/DNA-binding proteins fused in sarcoma (FUS) and TAR...

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PMID: 32344665
DOI: 10.3390/cells9041065

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