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Article

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.

Nature communications - 11 Sept 2018

Wang Haibo, Guo Wenting, Mitra Joy, Hegde Pavana M, Vandoorne Tijs, Eckelmann Bradley J, Mitra Sankar, Tomkinson Alan E, Van Den Bosch Ludo, Hegde Muralidhar L

Abstract excerpt

Genome damage and defective repair are etiologically linked to neurodegeneration. However, the specific mechanisms involved remain enigmatic. Here, we identify defects in DNA nick ligation and oxidative damage repair in a subset of amyotrophic lateral sclerosis (ALS) patients. These defects are caused by mutations in the RNA/DNA-binding protein FUS. In healthy neurons, FUS protects the genome by facilitating...

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Identifiers

PMID: 30206235
DOI: 10.1038/s41467-018-06111-6
PMCID: PMC6134028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.PMID 30206235Read ↗

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