Article

Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines

2023-03-24

Abstract excerpt

<h4>SUMMARY</h4> Personalized cancer vaccines (PCVs) largely leverage neoantigens arising from somatic mutations limiting their application to patients with relatively high tumor mutational burden (TMB). This underscores the need for alternative antigens to design PCVs for low TMB cancers. To this end, we substantiate endogenous retroviral elements (EVEs) as tumor antigens through large-scale genomic analyses of...

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Literature Corpus work: 5c3be894-7942-5d59-b505-f6f4e9c74d1e
DOI: 10.1101/2023.03.23.533908

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