Article

Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations

2025-02-14

Abstract excerpt

<h4>ABSTRACT</h4> To identify biomarkers and pathways to Type-2 diabetes (T2D), a major global disease, we completed array-based epigenome-wide association in whole blood in 5,709 Asian people. We found 323 Sentinel CpGs (from 314 genetic loci) that predict future T2D. The CpGs reveal coherent, nuclear regulatory disturbances in canonical immune activation pathways, as well as metabolic networks involved in insuli...

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Literature Corpus work: d4a914e8-a906-57b6-a05c-8c97ef871a15
DOI: 10.1101/2025.02.14.25322264

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