Article

Select autosomal dominant DFNA11 deafness mutations activate Myo7A in epithelial cells

2024-09-18

Abstract excerpt

<h4>SUMMARY</h4> Myosin-7A (Myo7A) is a motor protein crucial for the organization and function of stereocilia, specialized actin-rich protrusions on the surface of inner ear hair cells that mediate hearing. Mutations in Myo7A cause several forms of genetic hearing loss, including autosomal dominant DFNA11 deafness. Despite its importance, the structural elements of Myo7A that control its motor activity within ce...

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Literature Corpus work: bcee08e9-464c-5855-9fca-b679d30502d3
DOI: 10.1101/2024.09.17.613491

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