Article
Select autosomal dominant DFNA11 deafness variants activate Myo7A targeting in epithelial cells.
Journal of cell science - 1 Apr 2025
Acharya Prashun, Thapa Garima, Liao Xiayi, Matoo Samaneh, Graves Maura J, Atallah Sarah Y, Tipirneni Ashna K, Nguyen Tram, Chhabra Niki M, Maschack Jaden, Herod Mackenzie R, Ohaezu Favour A, Robison Alder, Mudaliyar Ashwini, Bharaj Jasvinder, Roeser Nicole, Holmes Katherine, Nayak Vishwaas, Alsayed Rayah, Perrin Benjamin J, Crawley Scott W
Abstract excerpt
Myosin-7A (Myo7A) is a motor protein crucial for the organization and function of stereocilia, specialized actin-rich protrusions on the surface of inner ear hair cells that mediate hearing. Variants in Myo7A cause several forms of genetic hearing loss, including autosomal dominant DFNA11 deafness. Despite its importance, the structural elements that control Myo7A within cells are not well understood. In this...
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