Article
A type VII myosin encoded by the mouse deafness gene shaker-1.
Nature - 2 Mar 1995
Gibson F, Walsh J, Mburu P, Varela A, Brown K A, Antonio M, Beisel K W, Steel K P, Brown S D
Abstract excerpt
Genetic deafness is common, affecting about 1 in 2,000 births. Many of these show primary abnormalities of the sensory neuroepithelia of the inner ear, as do several hearing-impaired mouse mutants, suggesting that genes involved in sensory transduction could be affected. Here we report the identification of one such gene, the mouse shaker-1 (sh1) gene. Shaker-1 homozygotes show hyperactivity, head-tossing and...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosomes, Artificial, Yeast
- DNA Primers
- Deafness
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Molecular Sequence Data
- Mutation