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Article

Myosin 7 and its adaptors link cadherins to actin.

Nature communications - 29 Jun 2017

Yu I-Mei, Planelles-Herrero Vicente J, Sourigues Yannick, Moussaoui Dihia, Sirkia Helena, Kikuti Carlos, Stroebel David, Titus Margaret A, Houdusse Anne

Abstract excerpt

Cadherin linkages between adjacent stereocilia and microvilli are essential for mechanotransduction and maintaining their organization. They are anchored to actin through interaction of their cytoplasmic domains with related tripartite complexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and Myo7b/ANKS4B/Harmonin in microvilli. Here, we determine high-resolution...

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PMID: 28660889
DOI: 10.1038/ncomms15864
PMCID: PMC5493754

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