Article

Cell Line-Specific Estrogen Responses Uncover Functional Sex Differences in Murine Macrophages

2025-06-30

Abstract excerpt

<title>Abstract</title> <p>Background RAW 264.7 (male-derived) and J774A.1 (female-derived), are widely used in immunology research, yet their responses to gonadal hormones remain poorly understood. Gonadal hormones, particularly estrogen, shape immune cell function and contribute to sex differences in disease outcomes, with macrophages playing a central role through their expression of intracellular estrogen re...

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Literature Corpus work: bccc4285-9077-539c-a3f7-b6f7d5fabd01
DOI: 10.21203/rs.3.rs-6925474/v1

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