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Article

Self-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge.

Scientific reports - 20 Mar 2017

Pepe Giovanna, Braga Daniele, Renzi Tiziana A, Villa Alessandro, Bolego Chiara, D'Avila Francesca, Barlassina Cristina, Maggi Adriana, Locati Massimo, Vegeto Elisabetta

Abstract excerpt

Beyond the physiology of reproduction, estrogen controls the homeostasis of several tissues. Although macrophages play a key role in tissue remodeling, the interplay with estrogen is still ill defined. Using a transcriptomic approach we first obtained a comprehensive list of genes that are differentially expressed in peritoneal macrophages in response to physiological levels of 17β-estradiol (E2) injected in...

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Identifiers

PMID: 28317921
DOI: 10.1038/srep44270
PMCID: PMC5357836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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