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Article

Relaxin-2 as a modifiable hormonal pathway in knee osteoarthritis: Dose dependent effects on chondrocyte phenotype.

PM & R : the journal of injury, function, and rehabilitation - 1 May 2026

Katz Nicole B, Khay Adam M, Dave Kandarp M, Casey Ellen, Ambrosio Fabrisia, Iijima Hirotaka

Abstract excerpt

BACKGROUND: Postmenopausal female individuals are disproportionately affected by knee osteoarthritis (KOA), experiencing earlier onset and more severe pathology compared to their male counterparts. Despite this clinical disparity, the molecular mechanisms underlying female-specific vulnerability remain poorly defined. OBJECTIVE: To evaluate the mechanistic role of relaxin-2 in postmenopausal KOA. DESIGN: This was...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 42037000
DOI: 10.1002/pmrj.70150

Genes

ACAN
ADAMTS4
PGC
SDHA
TOMM20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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