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Sex-linked Lung Estrobolome May Contribute to Pulmonary Hypertension Penetrance of <i>Bmpr2 R899X</i> Mutation via an ET-1 <sup>high</sup> Endoregulatory Macrophage Phenotype

2026-06-10

Abstract excerpt

Mutations in the bone morphogenetic protein receptor 2 (BMPR2) are a major genetic driver of pulmonary arterial hypertension (PAH), yet their penetrance is strikingly sex-biased: females are disproportionately affected, while males experience poorer outcomes. While hormonal and chromosomal factors have been implicated, the biological basis for this disparity remains not fully understood. Here, we investigated the...

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Literature Corpus work
a48410de-d1ee-5796-8fc5-cb664a217cbf
DOI
10.64898/2026.06.08.729693
Open publication

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Sex-linked Lung Estrobolome May Contribute to Pulmonary Hypertension Penetrance of <i>Bmpr2 R899X</i> Mutation via an ET-1 <sup>high</sup> Endoregulatory Macrophage PhenotypeDOI 10.64898/2026.06.08.729693
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