Back to search

Article

Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: application of<i>cis</i>-multivariable Mendelian randomization to<i>GLP1R</i>gene region

2023-07-25

Abstract excerpt

Phenotypic heterogeneity at genomic loci encoding drug targets can be exploited by multivariable Mendelian randomization to provide insight on the pathways by which pharmacological interventions may affect disease risk. However, statistical inference in such investigations may be poor if overdispersion heterogeneity in measured genetic associations is unaccounted for. In this work, we first develop conditional F-s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bcc00647-6700-50d5-b969-edc86caa62e3
DOI
10.1101/2023.07.20.23292958
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: application of<i>cis</i>-multivariable Mendelian randomization to<i>GLP1R</i>gene regionDOI 10.1101/2023.07.20.23292958
Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: Application of cis-multivariable Mendelian randomization to GLP1R gene region.Semantic proximity
Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian Randomization approachesSemantic proximity
Clustered Mendelian randomization analyses identify distinct and opposing pathways in the association between genetically influenced insulin-like growth factor-1 and type 2 diabetes mellitus.Semantic proximity
Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian randomization approaches.Semantic proximity
Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization.Semantic proximity
Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP).Semantic proximity
The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study.Semantic proximity
Two-Sample Multivariable Mendelian Randomization Analysis Using R.Semantic proximity
Select a neighboring publication to make it the new centre.