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Article

Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP).

Journal of human genetics - 1 Aug 2022

Maxwell Taylor J, Franks Paul W, Kahn Steven E, Knowler William C, Mather Kieren J, Florez Jose C, Jablonski Kathleen A

Abstract excerpt

The complex genetic architecture of type-2-diabetes (T2D) includes gene-by-environment (G×E) and gene-by-gene (G×G) interactions. To identify G×E and G×G, we screened markers for patterns indicative of interactions (relationship loci [rQTL] and variance heterogeneity loci [vQTL]). rQTL exist when the correlation between multiple traits varies by genotype and vQTL occur when the variance of a trait differs by...

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Share to Blood Glucose
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 35260800
DOI: 10.1038/s10038-022-01027-y
PMCID: PMC10102970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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