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Article

Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization.

Genetic epidemiology - 1 Oct 2022

Batool Fatima, Patel Ashish, Gill Dipender, Burgess Stephen

Abstract excerpt

When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines. Associations between variants in this cluster and stroke risk may be driven by any of these cytokines. Multivariable Mendelian randomization...

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Identifiers

PMID: 35638254
DOI: 10.1002/gepi.22462
PMCID: PMC9541575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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