Article
The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study.
International journal of epidemiology - 1 Aug 2020
Verkouter Inge, de Mutsert Renée, Smit Roelof A J, Trompet Stella, Rosendaal Frits R, van Heemst Diana, Willems van Dijk Ko, Noordam Raymond
Abstract excerpt
BACKGROUND: Body mass index (BMI)-associated loci are used to explore the effects of obesity using Mendelian randomization (MR), but the contribution of individual tissues to risks remains unknown. We aimed to identify tissue-grouped pathways of BMI-associated loci and relate these to cardiometabolic disease using MR analyses. METHODS: Using Genotype-Tissue Expression (GTEx) data, we performed overrepresentation...
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