Article
Clustered Mendelian randomization analyses identify distinct and opposing pathways in the association between genetically influenced insulin-like growth factor-1 and type 2 diabetes mellitus.
International journal of epidemiology - 13 Dec 2022
Wang Wenyi, Tesfay Ephrem Baraki, van Klinken Jan Bert, Willems van Dijk Ko, Bartke Andrzej, van Heemst Diana, Noordam Raymond
Abstract excerpt
BACKGROUND: There is inconsistent evidence for the causal role of serum insulin-like growth factor-1 (IGF-1) concentration in the pathogenesis of human age-related diseases such as type 2 diabetes (T2D). Here, we investigated the association between IGF-1 and T2D using (clustered) Mendelian randomization (MR) analyses in the UK Biobank. METHODS: We conducted Cox proportional hazard analyses in 451 232...
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