Article

Liver X Receptor activation protects Huntington’s disease knock-in mice from behavioral and neuropathological impairments

2025-12-01

Abstract excerpt

<title>Abstract</title> <p> Cholesterol homeostasis is crucial for brain function and is disrupted in neurodegenerative diseases such as Huntington’s disease (HD). Restoring brain cholesterol homeostasis has strong therapeutic potential, but the best options to this end have remained elusive. As Liver X Receptors (LXRα/β) control cholesterol homeostasis, we investigated the effect of LXR chronic activation using...

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Literature Corpus work: bc91109e-ddcf-5c31-a091-da73c9fd59c6
DOI: 10.21203/rs.3.rs-8155849/v1

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