Article

Inducible genetic ablation of <i>Immt</i> induces a lethal disruption of the MICOS complex

2023-08-23

Abstract excerpt

The mitochondrial contact site and cristae organizing system (MICOS) is important for cristae junctions (CJ) formation and for maintaining inner mitochondrial membrane (IMM) architecture. As the largest member, MIC60 is the primary scaffold protein for this complex. While MIC60 has been well studied in yeast and cell culture models, its function in mammals is poorly understood. To address this, we developed a mous...

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Literature Corpus work: a02a59b4-b5a0-5578-b7a3-913a714225d5
DOI: 10.1101/2023.08.22.554261

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