Article

A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex restrains excessive mitophagy to prevent mitochondrial disease

2022-11-12

Abstract excerpt

<h4>SUMMARY</h4> Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here via a mitochondria-targeted screen, we found that knockout (KO) of FBXL4, a mitochondrial disease gene, hyperactivates mitophagy at basal conditions. Subsequent counter screen revealed that FBXL4-KO hyperactivates mitophagy via two mitophagy...

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Literature Corpus work: 48d7451a-9aed-5148-a44a-9c9857475017
DOI: 10.1101/2022.11.11.516094

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