Article
Breast Cancer Risk in Women from Ghana Carrying Rare Germline Pathogenic Mutations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Aug 2022
Ahearn Thomas U, Choudhury Parichoy Pal, Derkach Andriy, Wiafe-Addai Beatrice, Awuah Baffour, Yarney Joel, Edusei Lawrence, Titiloye Nicholas, Adjei Ernest, Vanderpuye Verna, Aitpillah Francis, Dedey Florence, Oppong Joseph, Osei-Bonsu Ernest Baawuah, Duggan Máire A, Brinton Louise A, Allen Jamie, Luccarini Craig, Baynes Caroline, Carvalho Sara, Dunning Alison M, Davis Lynn Brittny C, Chanock Stephen J, Hicks Belynda D, Yeager Meredith, Chatterjee Nilanjan, Biritwum Richard, Clegg-Lamptey Joe Nat, Nyarko Kofi, Wiafe Seth, Ansong Daniel, Easton Douglas F, Figueroa Jonine D, Garcia-Closas Montserrat
Abstract excerpt
BACKGROUND: Risk estimates for women carrying germline mutations in breast cancer susceptibility genes are mainly based on studies of European ancestry women. METHODS: We investigated associations between pathogenic variants (PV) in 34 genes with breast cancer risk in 871 cases [307 estrogen receptor (ER)-positive, 321 ER-negative, and 243 ER-unknown] and 1,563 controls in the Ghana Breast Health Study (GBHS),...
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