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Discovery of structural deletions in breast cancer susceptibility genes using whole genome sequencing data from >2,000 African ancestry women

2020-08-10

Abstract excerpt

<title>Abstract</title> <p>Structural deletions in breast cancer susceptibility genes could confer to cancer risk, but remain poorly characterized. Here, we conducted in-depth whole genome sequencing (WGS) in germline DNA samples from 1,340 invasive breast cancer cases and 675 controls of African ancestry to discover such deletions. We identified 33 deletions, including five protein-truncating deletions in <itali...

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Literature Corpus work
3695d7d8-2638-51c1-bd7d-ea66760edf72
DOI
10.21203/rs.3.rs-50862/v1
Open publication

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Discovery of structural deletions in breast cancer susceptibility genes using whole genome sequencing data from &gt;2,000 African ancestry womenDOI 10.21203/rs.3.rs-50862/v1
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