Article

Multi-target Synergistic Regulatory Mechanisms of Aristolochic Acid-Induced Urothelial Carcinoma: Evidence from Network Toxicology and Molecular Dynamics

2025-12-22

Abstract excerpt

<title>Abstract</title> <p>Urothelial carcinoma (UC) is characterized by high incidence and recurrence rates, with aristolochic acid (AA) acting as a crucial pathogenic inducer that is closely associated with upper urinary tract UC. However, the molecular regulatory mechanisms underlying AA-UC interactions remain unclear, and traditional toxicological studies have inherent limitations. This study systematically e...

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Literature Corpus work: bc386208-91f1-5786-abc5-f13b25555849
DOI: 10.21203/rs.3.rs-8373310/v1

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