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Combining Network Toxicology with Machine Learning and Experiment Validation to Analyze the Molecular Mechanism and Core Target Screening of Aristolochic Acid Nephropathy

2026-01-28

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<title>Abstract</title> <p>This study aimed to comprehensively investigate the possible toxicity and molecular mechanisms of aristolochic acid (AA)-induced aristolochic acid nephropathy (AAN) and to provide a scientific basis for its prevention and treatment. Using network toxicology, machine learning, multidimensional bioinformatics, molecular docking, and molecular dynamics simulation, the study first collected...

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Literature Corpus work
930929ee-d2c3-5366-a892-7aaeb8003f60
DOI
10.21203/rs.3.rs-8558866/v1
Open publication

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