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Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1

2025-04-04

Abstract excerpt

During replication of some RNA viruses, defective particles can spontaneously arise and interfere with wild-type (WT) virus replication. Recently, engineered versions of these defective interfering particles (DIPs) have been proposed as an HIV-1 therapeutic. However, DIPs have yet to be reported in people with HIV-1 (PWH). Here, we find DIPs in PWH who have a rare, polyclonal form of non-suppressible viremia (NSV)...

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Identifiers and source

Literature Corpus work
bc1487f7-2d89-51fc-aee8-4851cc9ffad6
DOI
10.1101/2025.04.04.647291
Open publication

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Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1DOI 10.1101/2025.04.04.647291
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