Article
HIV-1 Superinfection Resembles Primary Infection.
The Journal of infectious diseases - 15 Sept 2015
Sheward Daniel J, Ntale Roman, Garrett Nigel J, Woodman Zenda L, Abdool Karim Salim S, Williamson Carolyn
Abstract excerpt
The relevance of superinfection as a model to identify correlates of protection against human immunodeficiency virus (HIV) depends on whether the superinfecting transmission resembles primary infection, which has not been established. Here, we characterize the genetic bottleneck in superinfected individuals for the first time. In all 3 cases, superinfection produced a spike in viral load and could be traced to a...
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