Article

Intragenic proviral elements support transcription of defective HIV-1 proviruses

2021-09-29

Abstract excerpt

<h4>ABSTRACT</h4> HIV-establishes a persistent proviral reservoir by integrating into the genome of infected host cells. Current antiretroviral treatments do not target this persistent population of proviruses which include latently infected cells that upon treatment interruption can be reactivated to contribute to HIV-1 rebound. Deep sequencing of persistent HIV proviruses has revealed that greater than 90% of i...

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Literature Corpus work: 3f17c999-b2c3-5c8b-897e-306dfdd81840
DOI: 10.1101/2021.09.29.462330

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