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Defective HIV-1 proviruses produce viral proteins

6 Feb 2020

Abstract excerpt

HIV-1 proviruses persist in the CD4 + T cells of HIV-infected individuals despite years of combination antiretroviral therapy (cART) with suppression of HIV-1 RNA levels <40 copies/mL. Greater than 95% of these proviruses detected in circulating peripheral blood mononuclear cells (PBMCs) are referred to as “defective” by virtue of having large internal deletions and lethal genetic mutations. As these defective...

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PMID: 32029589
DOI: 10.1073/pnas.1917876117

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