Article
HIV pathogenesis: dynamics and genetics of viral populations and infected cells.
Cold Spring Harbor perspectives in medicine - 1 Jan 2013
Coffin John, Swanstrom Ronald
Abstract excerpt
In the absence of treatment, HIV-1 infection, usually starting with a single virion, leads inexorably to a catastrophic decline in the numbers of CD4(+) T cells and to AIDS, characterized by numerous opportunistic infections as well as other symptoms, including dementia and wasting. In the 30 years since the AIDS pandemic came to our attention, we have learned a remarkable amount about HIV-1, the responsible...
Topics
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Dementia
- HIV Infections
- HIV-1
- Host-Pathogen Interactions
- Humans
- Mutation
- Opportunistic Infections
- T-Lymphocytes
- Virus Replication