Article

Progranulin Induces Immune Escape in Breast Cancer Via Up-Regulating PD-L1 Expression on TAMS and Promoting CD8+T cell Exclusion

2020-09-25

Abstract excerpt

<h4>Background: </h4> Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. <h4>Methods: </h4>: The changes of macrophage phenotypes after PGRN treatment were detected by western blot, quantitative PCR and flow cyto...

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Literature Corpus work: bc07dd82-3090-50ec-96ce-c2efce8bd26f
DOI: 10.21203/rs.3.rs-79474/v1

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