Article

cPLA2 Blockade Attenuates S100A7-Mediated Breast Tumorigenicity by Inhibiting the Immunosuppressive Tumor Microenvironment

2021-08-26

Abstract excerpt

<h4>Background: </h4> Metastasis is the major cause of mortality in breast cancer; however, the molecular mechanisms remain elusive. In our previous study, we demonstrated that S100A7/RAGE mediates breast cancer growth and metastasis by recruitment of tumor-associated macrophages. However, the downstream S100A7-mediated inflammatory oncogenic signaling cascade that enhances breast tumor growth and metastasis by ge...

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Literature Corpus work: 2886a3b6-e0cb-5801-93f2-92eeda07e4e9
DOI: 10.21203/rs.3.rs-829313/v1

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