Article

Regucalcin-containing extracellular vesicles suppress M2 macrophage polarization and attenuate tumor progression in vivo

2026-08-11

Abstract excerpt

Regucalcin (RGN) plays diverse roles in cell biology, highlighting its importance in both physiological and pathological conditions. Prostate cancer patients with higher RGN expression exhibited significantly longer disease-free survival. Although RGN is a cell signaling suppressor, the molecular mechanisms underlying tumor suppression by RGN in the tumor microenvironment through cell–cell communication remain unc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec13779a-a1df-5e22-a23f-def43deab7ef
DOI: 10.64898/2026.08.09.743746

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regucalcin-containing extracellular vesicles suppress M2 macrophage polarization and attenuate tumor progression in vivoDOI 10.64898/2026.08.09.743746Read

REG3β modifies cell tumor function by impairing extracellular vesicle uptake.Semantic proximity Read

Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment.Semantic proximity Read

Granulin <sup>+</sup> macrophages promote lineage plasticity in prostate cancer through paracrine signaling loopsSemantic proximity Read

Tumor-Derived miR-378a-3p-Containing Extracellular Vesicles Promote Osteolysis by Activating a Dyrk1a/Nfatc1/Angptl2 Axis for Bone MetastasisSemantic proximity Read

Progranulin Induces Immune Escape in Breast Cancer Via Up-Regulating PD-L1 Expression on TAMS and Promoting CD8+T cell ExclusionSemantic proximity Read

Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth.Semantic proximity Read

Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cellsSemantic proximity Read

RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cellsSemantic proximity Read

An Ex(o)citing Machinery for Invasive Tumor GrowthSemantic proximity Read

Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomesSemantic proximity Read

Ovarian cancer derived extracellular vesicles promote the metastasis and angiogenesis by mediating M2 macrophages polarizationSemantic proximity Read

The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate CancerSemantic proximity Read